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新型缓释辅料甲壳胺的研究 Ⅱ甲壳胺对不同性质药物的适应性的研究 被引量:1

The study of chitosan as sustained release tablets matrix Ⅱ the adaption of chitosan to drugs with different properties
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摘要 目的:考察甲壳胺对不同性质药物的适应性。方法:选择了盐酸麻黄碱,盐酸心得安,卡马西平,磺胺嘧啶,阿司匹林,法莫替丁,扑热息痛,潘生丁,茶碱,炎痛喜康,水杨酸等不同性质的11 种药物,以甲壳胺为阻滞剂,制备了缓释型骨架片剂,比较其溶出效果。结果:甲壳胺的缓释作用随药物碱性增强,分子量增大,溶解度降低而增强。 OBJECTIVE:To study the physical chemical properties of an active compound when releasing from chitosan matrix tablet.METHOD:The release rate of drugs with various variety solubility molecular weights and acidity or alkalinity through chitosan matrix tablets were studied.RESULTS:The solubility,molecular weights,and the acidity and alkalinity of drugs is important in the drug releasing from the chitosan matrix.CONCLUSION:Chitosan is a sustained release tablets matrix for drugs with different properities.
出处 《中国现代应用药学》 CAS CSCD 1999年第5期16-18,共3页 Chinese Journal of Modern Applied Pharmacy
关键词 甲壳胺 缓释片剂 药物性质 适应性 chitosan hydrophilic matrix tablet sustained relesase
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