摘要
目的:考察甲壳胺对不同性质药物的适应性。方法:选择了盐酸麻黄碱,盐酸心得安,卡马西平,磺胺嘧啶,阿司匹林,法莫替丁,扑热息痛,潘生丁,茶碱,炎痛喜康,水杨酸等不同性质的11 种药物,以甲壳胺为阻滞剂,制备了缓释型骨架片剂,比较其溶出效果。结果:甲壳胺的缓释作用随药物碱性增强,分子量增大,溶解度降低而增强。
OBJECTIVE:To study the physical chemical properties of an active compound when releasing from chitosan matrix tablet.METHOD:The release rate of drugs with various variety solubility molecular weights and acidity or alkalinity through chitosan matrix tablets were studied.RESULTS:The solubility,molecular weights,and the acidity and alkalinity of drugs is important in the drug releasing from the chitosan matrix.CONCLUSION:Chitosan is a sustained release tablets matrix for drugs with different properities.
出处
《中国现代应用药学》
CAS
CSCD
1999年第5期16-18,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
甲壳胺
缓释片剂
药物性质
适应性
chitosan
hydrophilic matrix tablet
sustained relesase