盐酸普鲁卡因经皮离子导入的研究

Study of iontophoresis of procaine hydrochloride

目的：考察盐酸普鲁卡因的离子导入与电流强度、药物浓度的关系。方法：测定不同的电流强度、不同的药物浓度的离子导入增渗倍数（ＥＲ） 。结果：固定药物浓度，电流强度为０ ．１ ，０ ．２ 和０ ．３ｍ Ａ 时的ＥＲ 值分别为６８ ，９９和１２７ 。固定电流强度为０ ．２ｍ Ａ，药物浓度为０ ．０１５１ ，０ ．０３０４ 和０ ．０６０５ｇ／１００ｍｌ 时的ＥＲ 值分别为９５ ，９９ 和９８ 。结论：离子导入可以显著提高药物渗透速率，增渗倍数（ＥＲ） 随着电流强度的增加而增加。

OBJECTIVE:To investigate the effects of current intensity and drug concentration on iontophoresis of procaine hydrochloride.METHODS:The enhancing rates different current intensities and different concentration have been determined.RESULTS:When the current strength of iontophoresis is 0.1,0.2 and 0.3mA,the ERs are 68,99 and 127 respectively.Keeping the current strength constantly(0.2mA),the ERs are 95,99 and 98 when the donor concentration is 0.0151,0.0304 and 0.0605g/100ml respectively.CONCLUSION:Iontophoresis increased the flux of drug obviously.The enhancing rate(ER) correlated closely to the current intensity,but had is no relationship with drug concentration.