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辅助性T细胞17和实验性自身免疫性葡萄膜炎 被引量：3

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摘要 辅助性T细胞17(T-helper type 17,Th17)是一种以分泌白介素-17(IL-17)为特征的辅助性T淋巴细胞亚型,在自身免疫性疾病中的作用逐渐得到重视。葡萄膜炎是最常见的致盲眼病,一直是眼科研究的热点和难点。实验性自身免疫性葡萄膜炎(experimental autoimmune uveoretinitis,EAU)是葡萄膜炎研究的成熟动物模型,有关Th17和EAU关系的研究处于起步阶段,现就这方面的研究现状进行综述,为葡萄膜炎的免疫机制研究提供新思路。
作者 龚文容 陈震 邢怡桥
机构地区 襄樊学院医学院/附属医院临床检验部 武汉大学人民医院眼科
出处 《华西医学》 CAS 2011年第2期301-304,共4页 West China Medical Journal
关键词 辅助性T淋巴细胞17 实验性自身免疫性葡萄膜炎 白介素-17
分类号 R773 [医药卫生—眼科]
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参考文献40

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同被引文献57

  • 1Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system[J]? Science, 2010, 330: 1768-1773.
  • 2Li Z, Liu B, Maminishkis A, et al. Gene expression profiling in autoimmune noninfectious uveitis disease [J]. J Immunol, 2008 , 181 : 5147-5157.
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  • 8Wildner G, Diedrichs-Mohring M, Thurau SR. Rat models of autoimmune uveitis [J]. Ophthalmic Res ,2008,40 : 141-144.
  • 9Rosenzweig HL, Martin TM, Planck SR, et al. Activation of NOD2 in vivo induces IL-Ibeta production in the eye via caspase-I but results in ocular inflammation independently of IL-I signaling [J]. J Leukoc Bioi, 2008,84: 529-536.
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二级引证文献7

华西医学
2011年 第2期

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