原因不明性肝炎血清TTVDNA的检出和意义

Detection of TTV Infection and Clinical Investigation in Patients with Hepatitis of Unknown Etiology

目的：调查原因不明性肝炎的ＴＴＶ感染状况。方法：设计ＴＴＶ基因的特异性引物，应用ＰＣＲ反应检测４８ 例原因不明性肝炎血清中的ＴＴＶ ＤＮＡ。结果：４８例原因不明性肝炎中１３ 例ＴＴＶ ＤＮＡ阳性（２７．１％ ），其中急性肝炎９ 例，慢性肝炎３ 例，亚急性重型肝炎１例。结论：ＴＴＶ感染是原因不明性肝炎的致病因子，ＴＴＶ 感染能引起急性。

Objective: We investigated investigate the presence of TTV infection among patients with hepatitis of unknown etiology. Methods: Forty eight serum samples from patients with hepatitis of unknown etiology were detected for TTV DNA by PCR methods. Results: The positive rate of TTV DNA accounted for 27.1% (13/48) in patients with hepatitis of unknown etiology. Among 13 patients with TTV DNA positive response, 7 were acute hepatitis, 5 were chronic hepatitis and 1 was subfulminant hepatitis. Conclusion: TTV infection could be associated with occurence of hepatitis, and could result in acute, chronic and fulminant hepatitis.