神经营养因子对帕金森病的修复作用

Repairing the parkinsonian brain with neurotrophic factors

PD是一种常见的慢性神经系统退行性病变，目前还没有任何有效的治疗方法可以减缓或预防其发病。神经营养因子作为一种前景广阔的PD治疗药物，目前正处于临床研究阶段。我们认为，要充分发挥神经营养因子的治疗功效，就必须在以下3个研究领域作出努力：首先，必须全面理解神经营养因子在老化多巴胺能神经元中的生理作用；其次，明确神经营养因子对病变神经元的神经保护、恢复和刺激作用的机制；再次，确保神经营养因子的快速有效传递以及神经元信号刺激的新方法能够达到临床应用效果。我们总结以上几个领域的进展，及提出神经营养因子生物学和疗法的新概念。

No therapy exists to slow down or prevent Parkinson＇s disease （PD）, a debilitating neurodegenerative disorder. Neurotrophic factors （NTFs） emerged as promising disease-modifying agents in PD and are currently under clinical development. We argue that efforts in three research areas must converge to harness the full therapeutic power of NTFs. First, the physiological roles of NTFs in aging dopaminergic neurons must be comprehensively understood. Second, the mechanisms underlying the neuroprotective, neurorestorative and stimulatory effects of NTFs on diseased neurons need to be defined. Third, improved brain delivery of Neurotrophic factors and new ways to stimulate NTF signaling are required to achieve clinical benefits. In this review, we discuss progress in these areas and highlight emerging concepts in NTF biology and therapy.