摘要
目的:评价NB-UVB治疗对银屑病患者血清细胞因子水平的影响。方法:采用双抗体夹心ELISA法,分别测定健康对照者、NB-UVB治疗前、后的银屑病患者血清中细胞因子IFN-γ、TNF-α、IL-4、IL-23的水平。结果:银屑病患者体内IFN-γ、TNF-α、IL-23水平明显增高,与健康对照组比较有显著性差异(P<0.001或P<0.01),且其水平高低与银屑病的病情程度相关;经NB-UVB治疗后,IFN-γ、TNF-α、IL-23水平明显降低,接近正常对照组水平。IL-4与对照组相比以及银屑病患者治疗前后均无明显变化。结论:NB-UVB照射治疗银屑病可能是通过调节T细胞、尤其是Th1细胞和抗原递呈细胞等免疫细胞的功能,从而影响细胞因子网络而起治疗作用。
Objective： To assess the effect of NB - UVB on the levels of serum cytokines in patients with psoriasis. Methods： The levels of serum IFN - γ, TNF-α, IL- 4 and IL - 23 were measured with sandwich ELISA in psoriasis patients and normal controls before and after UN - UVB irradiation. Results： The levels of IFN -γ, TNF - α and IL- 23 were significantly elevated in psoriasis patients when compared with normal controls （ P 〈 0.001 or P 〈 0.01 ）, and the levels were correlated to the severity of the disease. After NB - UVB irradiation, the levels of IFN - γ, TNF- αand IL- 23 were significantly decreased compared with that in normal controls. There was no significant difference in the level of IL - 4 between psoriasis patients and normal controls before and after NB - UVB irradiation. Conclusion： The therapeutic effect of NB - UVB irradiation may be through regulation of T cells, in particular Thl ceils and antigenpresenting cells, which influences cytokine network.
出处
《中国麻风皮肤病杂志》
2011年第1期9-11,共3页
China Journal of Leprosy and Skin Diseases
