20例布氏杆菌病临床分析

Clinical analysis of brucellosis in 20 cases

目的探讨呼和浩特地区布氏杆菌病的流行情况、临床症状、体征、化验检查及治疗结果。方法分析我科2008年3月—2009年12月20例布氏杆菌病住院患者的临床特征及治疗效果。结果本地区布氏杆菌病以冬春季为高发期;发病人群以从事养殖业及畜牧业的中青年男性为主;临床主要表现为发热、多汗、乏力及关节痛,部分患者查体可出现肝脾大,部分患者外周血白细胞数、血红蛋白及血小板可减低。治疗主要采取多西环素、利福平、左氧氟沙星3种抗菌素联合,1个疗程(6周)治愈率为85%。结论布氏杆菌病为呼和浩特地区发病率较高的传染病,须要高度重视从事养殖业及畜牧业人员的防疫,加强其自我防护意识,同时严格加强对病畜的检疫工作。在治疗方面主要采取抗生素联合治疗原则。

Objective To investigate the prevalence, clinical signs and symptoms, laboratory findings and treatment outcome of brucellosis in Hohhot. Method Clinical features and therapeutic efficacy were analyzed in 20 patients with brucellosis admitted to our hospital from Mar. 2008 to Dec. 2009. Results The incidence of brucellosis was higher in winter and spring in Hohhot and mainly in middle-aged males engaged in aquaculture and animal husbandry industry. The main clinical manifestations were fever, sweating, fatigue and joint pain, and hepatosplenomegaly was found in some patients. White Blood cell count, hemoglobin and platelets reduced in some patients. The combination therapy with doxycycline, rifampin and levofloxacin for 6 weeks was adopted with 85% of curative rate. Conclusions Brucellosis is a more frequent infectious disease in Hohhot, so it is emphasized to enhance the immunization of the personnel of aquaculture and animal husbandry industry, improve their awareness of self-protection and strengthen the quarantine of sick animals. Combination antibiotic therapy is effective.