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肝病中TGF-β与microRNAs相互作用的研究 被引量：1

Recent advance in interaction between TGF-β and microRNAs in liver disease
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摘要 TGF-β在肝病中发挥了复杂而关键的作用,与肝病的发生、发展和预后密切相关。microRNAs主要通过与靶mRNA的3'UTR结合,剪切mRNA或抑制蛋白质翻译,在转录后水平调节基因的表达。近来研究显示,TGF-β与microRNAs相互作用,参与调节肝病的发生发展。现将两者在肝纤维化、肝再生、肝脏发育和肝细胞癌中的相互调节作用做一概述。 TGF-β plays a complicated and critical role in liver disease,which is involved in the occurrence,development and prognosis of hepatopathy.MicroRNAs adjust gene expression mainly at the post-transcriptional level by binding 3＇UTR of target mRNA to cut it or inhibit the process of translation.Recent studies have shown that TGF-β and microRNAs can interact with each other and both participate in genesis and progress of liver fibrosis,liver regeneration and development and hepatocellular carcinoma.
作者 王世美 郑素军 段钟平
机构地区 山西医科大学附属第二临床医院消化内科 首都医科大学附属北京佑安医院人工肝中心
出处 《胃肠病学和肝病学杂志》 CAS 2011年第2期99-102,共4页 Chinese Journal of Gastroenterology and Hepatology
基金 "艾滋病和病毒性肝炎等重大传染病防治"科技重大专项课题(2008ZX10002-005-3) 国家自然科学基金资助项目(30800979) 北京自然科学基金资助项目(7102085) 北京市科技新星资助项目(2007B055) 首都医科大学基础-临床科研合作基金(2007JL02 2010JL02)
关键词 TGF-Β MICRORNA 肝纤维化 肝细胞再生 肝脏发育 肝细胞癌 TGF-β MicroRNA Liver fibrosis Liver regeneration Liver development Hepatocellular carcinoma
分类号 R575 [医药卫生—消化系统]
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参考文献29

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胃肠病学和肝病学杂志
2011年 第2期

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