TNF-α在IBD发病机制中的调节

Regulatory role of TNF-α in the pathogenesis of IBD

炎症性肠病(inflammatory bowel disease,IBD)是一种病因不明的肠道非特异性炎症性疾病,包括溃疡性结肠炎和克罗恩病,它们有各自的临床特征,内镜表现和组织学可区分;有学者认为它们是同一疾病的两个不同的阶段。在免疫应答中,TNF-α(TNF核心家族成员之一)作为细胞增殖和凋亡的主要促炎因子,在IBD的发病机制中起重要的调节作用。

Inflammatory bowel disease（IBD）,which includes Crohn＇s disease（CD） and ulcerative colitis（UC）,is a uncontrolled inflammatory of the gastrointestinal tract. The etiology is not clear yet.CD and UC have respective clinical features,they could be distinguished with endoscopy and histology.Some studies consider that CD and UC are different stages of development in IBD.In the immune response,TNF-α,as the main pro-inflammatory cytokines of cell proliferation and apoptosis,plays an important role in the regulation of the pathogenesis of IBD.