美他环素联合0.025%维A酸乳膏治疗寻常性痤疮疗效观察

Clinical research Metacycline combine 0.025% Tretinoin Cream to treat acne vulgaris LIU Na

目的:评价美他环素联合0.025%维A酸乳膏治疗中度寻常性痤疮的疗效与安全性。方法:将116例寻常性痤疮患者随机分为治疗组和对照组,治疗组59例,口服美他环素胶囊0.3g,2次/天;对照组57例,口服甲硝唑片0.2g,3次/天;两组均于睡前外用0.025%维A酸乳膏,每天1次,疗程4周。结果:治疗组痊愈率为62.7%,有效率94.9%;对照组分别为28.1%,71.9%;两组痊愈率和有效率比较差异均有统计学意义(χ2=2.48,2.77,P<0.01)。结论:美他环素联合0.025%维A酸乳膏治疗中度寻常性痤疮疗效确切,安全性高。

Objective To evaluate the efficacy and safety about Metacycline combining 0.025% Tretinoin Cream to treat acne vulgaris.Methods 116 acne vulgaris＇ patients were incorporated into two groups： treatment group and matched group.Group A： 59 patients were taken orally Metacycline capsules 0.3,twice a day.Group B： 57 patients were taken orally Metronidazole tablets 0.2,three times a day.Both groups were used 0.025% Tretinoin Cream before sleep for use external,once a day.The course of treatment： 4 weeks.Results The care rate： Group A 62.7%,Group B 28.1%.The effective rate： Group A 94.9%,Group B 71.9%.The comparative differences between the two groups＇ care rate and effective rate have statistical significance（χ2=2.48,P0.01）.Conclusion Metacycline is a very good antibiotic to treat the acne vulgaris.This treatment is efficacious and safe.