红景天口服液对氢化可的松致阳虚模型大鼠保护作用初步研究

A Preliminary Study on Protective Action of Rhodiola Crenulate Oral Liquid on Rat's Yang Deficiency Induced by Hydrocortisone

目的:研究红景天口服液对氢化可的松致大鼠阳虚模型动物的保护作用。方法:雄性SD大鼠30只,每组6只,肌肉注射氢化可的松建立大鼠阳虚模型。给药第8天,开始灌胃给予生理盐水(空白对照、模型对照)、男宝胶囊、红景天口服液2.48、24.80 g/kg(低剂量组和高剂量组),连续30天。观察动物的血清睾酮、心脏、肝脏、性器官、免疫器官重量,测定血清中SOD和MDA水平等指标变化。结果:红景天口服液具有改善体内睾酮水平,减缓附性器官萎缩,提高体内抗氧化水平的能力。结论:红景天口服液对于"阳虚"动物模型可能具有保护作用。

Objective：To observe the protective action of Rhodiola Crenulate Oral Liquid（RCOL） on rat＇s Yang deficiency induced by hydrocortisone.Methods： 30 SD rats were randomly divided into 5 groups with 6 rats each group.The rat model of Yang deficiency was induced by intramuscular injection of hydrocortisone.On the eighth day of administration,physiological saline（blank control and model control） Nan-bao capsule,RCOL 2.48,24.80 g/kg were treated by oral administration for 30 days.The serum testosterone,the weight of heart,liver,sex organs,immune organs and serum SOD and MDA levels were observed.Results： The RCOL could improve testosterone levels,slow down the sex organs shrink and enhance the ability of antioxidation.Conclusion： RCOL could have an protective action in Yang deficient rats.