不同ER状态乳腺癌组织Bcl-2的表达及其临床意义

Expression and significance of Bcl-2 in breast cancer with different ER status

目的分析不同ER状态的乳腺癌组织中Bcl-2表达情况及其意义。方法采用免疫组织化学方法检测160例浸润性乳腺癌组织中ER和Bcl-2的表达情况,依据ER状态分为ER阳性和阴性组,分别比较Bcl-2表达与临床病理特征的关系。结果 160例乳腺癌组织中ER阳性为70例(43.8%),Bcl-2阳性74例(46.3%),Bcl-2与ER表达呈正相关。ER阳性组中Bcl-2表达与淋巴结转移少、组织学分级低及临床分期早显著相关,ER阴性组中Bcl-2表达与上述临床病理特征均无关。结论乳腺癌组织中存在Bcl-2表达,其中ER阳性乳腺癌组织中Bcl-2表达与临床病理特征有相关性。

Objective To investigate the expression and significance of Bcl-2 in breast cancer with different ER status.Methods Expression of ER and Bcl-2 was evaluated by immunohistochemical staining in 160 cases of breast cancer.All the cases were divided into two groups（ER-positive group and ER-negative group） according to ER status,and then to analyze the relationship between the expression of Bcl-2 and clinicopathological features in each group.Results In 160 cases of invasive breast cancer,70 cases（43.8%） were ER positive and 74 cases（46.3%） were Bcl-2 positive,and the expression of Bcl-2 was positively correlated with ER.In ER positive group,the expression of Bcl-2 was inversely correlated with lymphatic metastasis and positively correlated with low histological grade and low clinical stage,but in ER negative group,there was no correlation between the expression of Bcl-2 and clinicopathological features.Conclusion There is positive expression of Bcl-2 in breast cancer tissues,which is correlated with clinicopathological features of breast cancer patients.