摘要
重链病（heavy chain diseases，HCD）是一组临床少见的B淋巴细胞系浆细胞异常增殖导致的疾病，其特征是合成不完全的单克隆免疫球蛋白重链而不伴随有轻链的生成^［1］，致使血清和尿中出现大量游离的无免疫功能的免疫球蛋白重链。该病根据重链的不同可进行免疫分型，以d型为最多见，其他类型也有报道，而ε重链病尚未见报道。自从1964年首例y型重链病被Franklin等^［2］报道以来，目前世界范围内文献报道约有120例。最近我们发现1例y型重链病，现报告如下。
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2011年第2期179-180,共2页
Chinese Journal of Laboratory Medicine
参考文献3
-
1Wahner-Roedler DL,Kyle RA.Heavy chain diseases.Best Pract Res Clin Haematol,2005,18:729-746.
-
2Franklin EC,Lowenstein J,Bigelow B,et al.Heavy chain disease:a new disorder of serum γ-globulins.Am J Med,1964,37:332-350.
-
3侯健,张春阳.重链病的诊断与治疗[J].中国实用内科杂志,2007,27(19):1499-1502. 被引量：6
二级参考文献14
-
1Fine KD,Stone MJ.Alpha-heavy chain disease,mediterranean lymphoma,and immunoproliferative small intestinal disease:a review of clinicopathological features,pathogenesis,and differential diagnosis[J].Am J Gastroenterol,1999,94:1139-1152.
-
2Halphen M,Najjar T,Jaafoura H,et al.Diagnostic value of upper intestinal fiber endoscopy in primary small intestinal lymphoma:a prospective study by the Tunisian-French Intestinal Lymphoma Group[J].Cancer,1986,58:2140 -2145.
-
3Agrawal S,Abboudi Z,Matutes E,et al.First report of fludarabine in gamma-heavy chain disease[J].Br J Haematol,1994,88:653-655.
-
4Khojasteh A,Saalabian MJ,Haghshenass M.Randomized comparison of abdominal irradiation (AI)vs CHOP vs C-MOPP for the treatment of immuno-proliferative small intestinal disease (IPSID)associated lymphoma(AL)[J].Proc Annu Meeting Am Soc Clin Oncology,1983,2:207.
-
5Ben-Ayed F,Halphen M,Najjar T,et al.Treatment of alpha chain disease:results of a prospective study in 21 Tunisian patients by the Tunisian-French Intestinal Lymphoma Study Group[J].Cancer,1989,63:1251-1256.
-
6Akbulut H,Soykan I,Yakaryilmaz F,et al.Five-year results of the treatment of 23 patients with immunoproliferative small intestinal disease:a Turkish experience[J].Cancer,1997,80:8-14.
-
7Yanai M,Maeda A,Watanabe N,et al.Successful treatment of mu-heavy chain disease with fludarabine monophosphate:a case report[J].Int J Hemato1,2004,79:174-177.
-
8Ernest B,Marshall AL,Barry SC,et al.Williams hematology[M].6th ed.New York:McGraw-Hill Professional,2000:19-31.
-
9Fermand JP,Brouet JC,Danon F,et al.Gamma heavy chain ' disease':hetero-geneity of the clinicopathologic features:report of 16 cases and review of the literature[J].Medicine (Baltimore),1989,68:321 -335.
-
10Wahner-Roedler DL,Witzig TE,Loehrer LL,et al.Gamma-heavy chain disease:review of 23 cases[J].Medicine (Baltimore),2003,82:236-250.
共引文献5
-
1闫会昌,张江安,于建斌,王祖艳.M蛋白血症的皮肤表现[J].中国皮肤性病学杂志,2016,30(12):1295-1297. 被引量：1
-
2段雪,王伟,李广伦,刘晓丹,吴颖.以左颈部淋巴结大伴胀痛为主要表现的重链病1例并文献复习[J].青岛大学学报（医学版）,2018,54(2):236-237. 被引量：1
-
3贾子超,张晓方,孙颖,曹灿,胡志东,罗微.血清游离轻链对克隆性浆细胞病诊疗价值的研究进展[J].检验医学与临床,2019,16(3):424-427. 被引量：3
-
4郑伟,陆捷,郝爱军,张银辉,王东云.α重链病临床特征和实验室检查特征[J].检验医学与临床,2020,17(9):1250-1253.
-
5邵淑丽,邓秀芝,王赞,李彬彬,曲业敏.1例特殊的伴重链病的T细胞淋巴瘤[J].医学检验与临床,2022,33(5):74-76.
-
1侯健.M蛋白的鉴定及结果分析[J].中华血液学杂志,2002,23(10):558-560. 被引量：13
-
2刘涛,胡爱霞,袁慧中.重链沉积病一例[J].中国医师杂志,2014,16(12):1724-1726.
-
3陶江川,李甘地,杨光华,杨秀英,刘卫平.应用PCR检测石蜡包埋骨髓活检标本B淋巴细胞克隆性增生[J].华西医科大学学报,1994,25(4):402-405.
-
4李桢,邹红岩,吴国光,程良红,王大明,唐斯.HLA新基因B"非汉字符号"610携带者家系B淋巴细胞系的建立[J].中国输血杂志,2004,17(5):308-310. 被引量：2
-
5陶国枢.糖尿病合并高血压的循证治疗(三)[J].保健医苑,2005(12):24-26.
-
6常玉梅.M蛋白的鉴定及实验分析[J].实用医技杂志,2007,14(27):3821-3822. 被引量：1
-
7苏红波,赵秀玲,张兰香,赵旭.肺癌手术患者的护理及并发症的预防[J].大家健康（学术版）,2014(11):241-241.
-
8安云庆,滕树华.医学免疫学(辅导讲座二)[J].中华护理杂志,1989,24(1):43-46.
-
9林法迎,侯健,谭龙益,丁思奇,王皓,王东星.实时定量PCR监测多发性骨髓瘤患者自体造血干细胞移植后微小残留病[J].中国实验血液学杂志,2003,11(5):516-520. 被引量：7
-
10朱忆思梦,董李朵,张树辉.胃癌细胞增殖与相关基因的表达[J].按摩与康复医学,2012,3(32):10-10.
