P-糖蛋白表达与维吾尔族、汉族宫颈癌新辅助化疗疗效相关性研究

Relationship between the expression of P-glycoprotein and the therapeutic effect of neoadjuvant chemotherapy on Uygur and Han patients with cervical cancer

目的:探讨耐药基因产物P-糖蛋白(P-glycoprotein,P-gp)的表达与维吾尔族(维族)、汉族宫颈癌新辅助化疗疗效的相关性。方法:62例宫颈癌患者(宫颈癌组)中汉族40例,维族22例,均接受新辅助化疗;50例宫颈组织正常者(对照组)中汉族30例,维族20例。应用免疫组织化学SP法检测2组P-gP的表达情况,并进行比较。结果:2组P-gp的表达在维、汉2个民族间差异无统计学意义(P>0.05);宫颈癌组P-gp表达水平明显高于对照组,差异有统计学意义(P<0.05)。新辅助化疗有效率P-gp表达阳性患者(72.5%)明显低于表达阴性患者(100.0%)(P<0.05),新辅助化疗疗效在维、汉2个民族间差异无统计学意义(P>0.05);P-gp表达与民族、新辅助化疗疗效、临床分期、分化程度及淋巴结转移均无相关性(P>0.05)。结论:P-gp的表达可能与宫颈癌发生、发展相关,P-gp的表达不仅在宫颈癌耐药机制中发挥重要作用,且与化疗疗效密切相关。

Objective To explore the relationship between the expression of P-glycoprotein and the therapeutic effect of cervical neoadjuvant chemotherapy on Uygur and Han patients with cervical cancer.Methods Sixty-two cervical cancer patients（cervical cancer group）,including 40 Han patients and 22 Uygur patients,received neoadjuant chemotherapy,and another 50 cases of normal cervical tissue（control group） included 30 Han cases and 20 Uygur cases.The expression of P-glycoprotein was detected with immunohistchemistry S-P technique and in two groups and compared between two groups.Results There was no significant difference in the expression of P-glycoprotein between Uygur and Han nationalities（P0.05）.The expression of P-glycoprotein was significantly higher in cervical cancer than that in normal cervical tissue（P0.05）.The chemotherapy effective rate was lower in patients with positive P-glycoprotein（72.5%） than that in patients with negative P-glycoprotein（100%）（P0.05）.There was no significant difference in cervical neoadjuvant chemotherapy therapeutic effect between Han and Uygur nationalities（P0.05）.The expression of P-glycoprotein was not correlated with the nationality,therapeutic effect of neoadjuvant chemotherapy,the clinical stages,the histological grading or lymph node metastasis（P0.05）.Conclusion The expression of P-glycoprotein might be correlated with the occurrence and development of cervical cancer.It plays an important role in cervical cancer drug resistance mechanism,and is closely correlated with the effect of neoadjuvant chemotherapy.