摘要
乙酰肝素酶(HPSE)是目前在哺乳动物中发现的可以降解硫酸乙酰肝素蛋白聚糖(heparan sulfate proteoglycans,HSPGs)上的硫酸肝素(HS)糖链的一类6-D糖苷内切酶。其在肿瘤侵袭转移中起着关键作用。本文就HPSE分子结构、生物学特征、在恶性肿瘤中的表达、促进肿瘤转移机制及HPSE抑制剂的应用等方面作一综述。
Heparanase, an endo-β-D-glucuronidase, that cleaves heparan sulfate chains in heparan sulfate proteoglycans, has recently been found in mammalian. It may play a key role in tumor progression and metastasis. Here we disscuss its molecular structure, biochemical properties, expression in malignant tumor, mechanism in accelerating tumor metastasis and application in heparanase inhibitor.
出处
《国际外科学杂志》
2011年第3期170-172,共3页
International Journal of Surgery
基金
南京军区“十一五”科研规划重点课题(No.07Z038)