摘要
血红素加氧酶-1（heine oxygenase-1，HO-1）通过分解血红素产生一氧化碳、胆绿素、胆红素及亚铁离子，可以减轻炎性介质反应，拮抗细胞氧化损伤和细胞应激从而发挥细胞保护作用。基因转染的方法能够维持目的基因的长时间表达，可以调节细胞因子的免疫反应。HO-1基因转染已在其他疾病的治疗研究中取得良好成果，本文针对HO-1基因转染治疗急性胰腺炎的可行性进行综述。
Heme oxygenase- 1 （ HO- 1 ） can catalyze the decomposition of heme and the products of its enzymatic activity,including carbon monoxide, biliverdin, bilintbin and ferritin, can play a significant eytoprotective role in antagonizing inflammation, protecting cells from oxidative injury and cellular stresses. The method of gene transfer can maintain target gene expression for a long time, can regulate the inflammatory immune response. HO-1 gene transfer has made marked results in research of numerous diseases. In this article, we give a review of feasibility of HO-1 gene transfer therapy in acute pancreatitis.
出处
《国际外科学杂志》
2011年第3期176-179,共4页
International Journal of Surgery
