孕育神经管缺陷儿的育龄妇女生命质量及相关因素

Quality of life and related factors of childbearing age women conceiving fetus with neural tube defects

目的:了解孕育神经管缺陷儿(neural tube defects,NTDs)母亲的生命质量状况及相关因素,为孕育NTDs及其他出生缺陷儿母亲生命质量的干预提供科学依据。方法:采用1∶1匹配病例对照研究,以141例孕育NTDs的母亲和141例分娩正常儿的母亲为研究对象,用WHO生存质量量表简表-中文版(World Health Organization quality of life questionnaire-BREF,WHOQOL-BREF)进行生命质量测评。结果:在调整可能的混杂变量后,病例组和对照组生命质量总分差异无统计学意义[(98.6±10.4)vs.(99.1±9.9),P=0.822]。病例组心理领域得分低于对照组[(13.5±2.1)vs.(14.0±1.8),P=0.040],且生命质量和健康状况总分也低于对照组[(14.4±2.4)vs.(14.9±2.4),P=0.036]。孕育NTDs母亲家庭摩擦越少、食欲越好、夫妻关系越好和自评得分越高,其生命质量得分越高。结论:孕育NTDs母亲生命质量总得分与对照组无差别,心理领域和总的生命质量和健康状况得分低于对照组。在以后的妇幼卫生工作中,对家庭关系较差的孕育NTDs妇女给予关注并进行适当的心理干预,以改善该群体的生命质量。

Objective：To explore the quality of life（QOL）of childbearing age women conceiving fetus with neural tube defects（NTDs）and related factors,in order to provide scientific basis for the improvement of QOL of the mothers of NTDs and other birth defects.Methods：In this 1∶1 matched case-control study,141 women who had given birth or had abortion with NTDs newborns or fetus were included in case group,and 141 women who had given birth to normal babies were include in control group in Shandong Province.The QOL of the study subjects were assessed with the WHO quality of life questionnaire-BREF（WHOQOF-BREF）.Results：When adjusted the potential confounding effect of the social and demographic factors,the difference of the total score between case group and control group was not statistically significant [（98.6±10.4）vs.（99.1±9.9）,P=0.882].The psychological domain score of the case group was lower than that of the control group[（13.5±2.1）vs.（14.0±1.8）,P=0.040],and the overall quality of life and health status score of the case group was lower than that of the control group[（14.4±2.4）vs.（14.9±2.4）,P=0.036],and no statistically differences was found in the remaining domains.Little family friction,good appetite,good spousal relationship and high score of self-evaluation were significantly positively correlated with the high total score of QOL of the case group.Conclusion：〖WTBZ〗There are no differences of QOL total score between case group and control group,but the scores of psychological domain and the overall QOL and health status in the case group are lower than that of the control group.Attention and mental intervention should be given to the case women with poor family relationships,so that to improve the QOL of this population in the maternal health care.