112例急性胰腺炎凝血功能检测的临床意义

Clinical Significance of Alteration of coagulation function in 112 patients with Acute pancreatitis

目的:探讨急性胰腺炎(AP)患者血浆凝血系统的变化、发病机制及临床意义。方法:112例AP患者中SAP组48例,MAP组64例。检测患者血浆凝血指标PT、APTT、FIB、D-D二聚体。结果:与MAP组比较,SAP组PT、APTT、FIB及D-dimmer差异均有统计学意义。D-dimmer与APACHEⅡ评分有一定相关性。SAP组病死率(6.25%)与MAP组(0)比较有明显差异。结论:SAP患者存在血浆凝血功能紊乱及微循环障碍,检测血浆凝血指标有助于评估AP患者的病情及预后。

Objective：To evaluate the changes of blood coagulation and their clinical significance in patients with acute pancreatitis.Methods：One hundred and twelve patients acute pancreatitis were recruited in this study.Patients were divided into two groups,severe acute pancreatitis（48 cases）and mild acute pancreafitis（64 cases）,according to the diagllostic criteria set by the Chinese Medical Association in 2004.Plasma coagulation parameters including prothrombin time（PT）,activated partial thromlooplastin time（APTT）,fibrinogen（FlB）and D-dimmer were redorded.Results ：Com-Pared with MAP group,there were significant differences On APTT、PT、FIB and D-dimmer in SAP group.D-dimmer was correlated to the APACHE II score.the morality were higher in patients with SAP patients than those in the MAP patients.Conclusions ：Disorders of coagulation and microcirculation disturbances were observed in patients with severe acute pancreatitis.These alterations may be useful in the assessment of the disease severity and prognosis of patients with acute pancreatitis.