某市新生儿败血症病原学及耐药性分析

Study on etiology and drug resistance of neonatal septicemia in some city

目的分析某市新生儿血培养病原菌分布及耐药情况,为指导临床明确病原及合理应用抗菌剂提供依据。方法对该院3 420例新生败血症患儿无菌采集血液进行细菌培养并进行耐药性分析。结果检出病原菌515株,阳性率为15.1%,其中革兰阳性菌396株,占76.9%;革兰阴性菌为110株,占21.4%;真菌9株,占1.7%。葡萄球菌对多种抗菌剂耐药,对万古霉素全部敏感;大肠埃希菌和肺炎克雷伯菌对一、二代头孢菌素耐药率较高,且对三代头孢菌素的耐药率有上升的趋势,对亚胺培南敏感率较高。结论该市新生儿血培养病原菌以革兰阳性球菌为主。

Objective To analyze the etiology and drug resistance of neonatal septicemia in Xi＇an,and provide a basis for clinical medication. Methods Blood samples of 3 420 neonates suspected as septicemia were collected and cultured to test drug resistance from June 2009 to June 2010. Results 515 samples were pathogen positive in blood culture test, which accounts 15.1 ~ in 3 420 samples. 396 of 512 samples were gram-positive bacteria, 76.9%;110 were gram negative bacteria, 21.4%/00;9 were fungi, 1.7%. Staphylococcus was resistant to several antibiotics,but sensitive to vancomycin. Escherichia coli and Klebsiella pneumonia were resistant to first generation and second generation cephalosporin,and inclined to resistant to third generation cephalosporin, but were still sensitive to imipenem. Conclusion Pathogen of neonatal blood culture tests are primarily gram-positive cocci in Xiran. Clinicians should choose proper antibiotics according to the results of blood culture and drug sensitivity test,in order to reduce occurence of resistant strains.