急性冠脉综合征患者血清基质金属蛋白酶-9与超敏C反应蛋白检测的临床意义

The clinical significance of serum matrix metalloproteinase-9 and high-sensitive C-reactive protein in patients with acute coronary syndrome

目的研究急性冠脉综合征(ACS)患者血清中的基质金属蛋白酶-9(MMP-9)和超敏C反应蛋白(hs-CRP)的水平变化,探讨其在ACS诊断和预测中的临床价值。方法选取临床确诊的ACS患者53例,其中急性心肌梗死(AMI)组24例,不稳定型心绞痛(UA)组29例,以同期、同年龄健康体检者30例作为对照。分别采用酶联免疫吸附法(ELISA)检测血清MMP-9浓度和免疫透射比浊法检测血清hs-CRP浓度。结果 AMI组和UA组患者血清MMP-9和hs-CRP浓度均明显高于对照组,差异有统计学意义(P<0.01),且AMI组患者与UA组患者间比较也存在统计学差异(P<0.01),AMI组患者在发病初期与治疗后血清MMP-9和hs-CRP水平比较也存在统计学差异(P<0.01)。结论 ACS患者血清MMP-9、hs-CRP水平是2个有价值的冠脉损伤的指标,可作为冠脉事件预测的重要参数。

Objective To investigate the changes of matrix metalloproteinase^9 （MMP 9） and high-sensitivity C-reactive protein （hs CRP） concentration in serum of patients with acute coronary syndrome（ACS）, and to evaluate its clinical significance in ACS diagnosis and prognosis. Methods 53 patients with ACS, which acute myocardial infarction 24 cases, unstable angina 29 cases, and 30 normal people were included in the study. Serum MMP-9 levels were detected by EIdSA, the immune turbidimetric assay was used to measure the serum hs CRP levels. Comparison analyze were performed by using SPSS11.5 statisfical package. Results The serum MMP-9 and hs CRP levels in ACS patients were significantly higher than the normal group （P^0.0l）. There was a significant difference between AMI group and UA group（P^0.05）,and the same significant difference between acute infarction group and recovery infarction group（P^0.05）. Conclusion The levels of serum MMP-9 and hs CRP remarkably increase in the patients with ACS. They are two sensitive items also important parameters of assessing the prognosis.