期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血清Dickkopf-1水平在诊断肺癌及其骨转移中的应用价值 被引量：2

下载PDF
导出
摘要 目的分析血清Dickkopf-1(DKK1)水平在肺癌及其骨转移中的变化,应用ROC曲线评价其在肺癌诊断中的价值。方法将116例肺癌患者根据骨转移程度分为未转移组、局限转移组和广泛转移组,另外收集82例肺结核患者作为疾病对照组和105例健康体检者作为健康对照组。所有对象均测定血清DKK1和细胞角蛋白19片段(Cyfra21-1)水平,绘制ROC曲线并计算曲线下面积(AUC)。结果与健康对照组比较,疾病对照组与肺癌各组血清DKK1水平均显著升高(P<0.05);采用DKK1和Cyfra21-1分别诊断肺癌的ROC AUC分别为0.794和0.738,两项联合诊断的AUC为0.854,比单项检测的AUC明显提高(P<0.05)。结论血清DKK1水平的升高可能与肺癌的发生相关,联合测定血清DKK1和Cyfra21-1可提高肺癌诊断准确性。
作者 徐吟亚
机构地区 武汉钢铁集团总医院检验科
出处 《国际检验医学杂志》 CAS 2011年第3期379-380,共2页 International Journal of Laboratory Medicine
关键词 肺肿瘤 骨转移 DICKKOPF-1
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1杜红心,罗海峰,彭必江,陈蓉,程钢,林岚.联合检测CEA、NSE和CYFRA21-1在肺癌诊断中的价值[J].国际检验医学杂志,2010,31(5):447-448. 被引量：13
  • 2黄诚刚,苏莉,陈晓艳,邓燕,宓平.67例肺癌ECT全身骨显像及血清Cyfra21-1、NSE、CEA、CA125联合测定分析[J].国际检验医学杂志,2010,31(5):451-453. 被引量：15
  • 3Licchesi JD,Van Neste L, Tiwari VK,et al. Transcriptional reguation of Wnt inhibitory factor-1 by Miz-1/c-Myc[J]. Oncogene, 2010,29(44) :5923-5934.
  • 4yon Marschall Z, Fisher L. Secreted frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling [J]. Biochem Biophys Res Commun,2010,400(3):299-304.
  • 5Wang J,Shou J,Chen X. Dickkopf-1,an inhibitor of the Wnt sig naling pathway,is induced by p53[J]. Oncogene, 2000, 19(14): 1843-1848.
  • 6Filipovich A, Gandhirajan RK,Gehrke I, et al. Evidence for non- functional Dickkopf-1 (DKK-1) signaling in chronic lymphocytic leukemia(CLL)[J]. Eur J Haematol,2010,85(4) :309-313.
  • 7Granchi D, Corrias MV, Garaventa A, et al. Neuroblastoma and bone metastases:clinical significance and prognostic value of DickL kopf 1 plasma levels[J]. Bone, 2010,48 (1) : 152-159.
  • 8Thompson MD, Monga SP. WNT/ catenin signaling in liver health and disease[J]. Hepatology,2007,45(2) : 1298-1305.
  • 9Willert K,Brown JD,Danenberg E,et al. Wnt proteins are lipid modified and can actas stem cell growth factors[J]. Nature,200a, 423(4) :448-452.
  • 10He X, Semenov M, Tamai K, et al. LDL reeeptorrelated proteins 5 and 6 in Wnt/beta-catenin signaling; arrows point the way[J].Development, 2004,131 (2) : 1663-1677.

二级参考文献16

  • 1高海锋.肿瘤标记物CA125检测在诊断肺癌中的价值[J].实用医技杂志,2008,15(9):1217-1218. 被引量：5
  • 2时广利,胡秀玲,岳思东,宋长兴.血清肿瘤标志物在肺癌辅助诊断中的应用[J].中华肿瘤杂志,2005,27(5):299-301. 被引量：82
  • 3宋现让,刘美琴,朱传金,刘利胜.神经元特异性烯醇化酶检测的标本因素探讨[J].医学检验与临床,2006,18(4):69-70. 被引量：5
  • 4廖秋林,李莲花,陈铭声.肺癌患者血清sTNFR、CEA和NSE的检测及其临床意义[J].中国现代医学杂志,2006,16(11):1635-1638. 被引量：7
  • 5Ando S,SuzukiM,Yamamoto N,et al.The prognostic value of both neuron2specific enolase(NSE)and Cyfra21-1 in small cell cancer[J].Anticancer Res,2004,24(3):1941-1946.
  • 6Pujol JL,Boher JM,Grenier,et al.Neuron specitic enolase and prognosis of non-small cell lung cancer:prospective study in 621 patients[J].Lung cancer,2001,31 (2):221-228.
  • 7Raso MG,Wistuba II.Moleculai pathogenesis of early-stage non-small cell lung cancer and a proposal for tissue banking to facilitate identification of new biomarkers[J].J Thoraciconcol,2007,2(7):128 -135.
  • 8Schneider J.Tumormarkers in detection of lung cancer[J].Adv Clin Chem,2006,42(1):39-41.
  • 9OREMEK GM,SAUER-EPPEL H,BRUZDZIAK TH.Value of tumour and inflammatory markers in lung cancer[J].Anticancer Res,2007,27(4A):1911-1915.
  • 10LI CS,CHENG BC,GE W,et al.Clinical value of CY-FRA21-1,NSE,CA15-3,CA19-9 and CA125 assay in the elderly patients with pleural effusions[J].Int J Clin Pract,2007,61(3):444-448.

共引文献25

同被引文献33

  • 1余艳军,万晓桢,于彬,游海燕,舒惠群,姚根富,覃文新.Dickkopf(DKK1)在肝癌组织及多种人肿瘤细胞系中的表达分析[J].肿瘤,2006,26(12):1109-1112. 被引量：16
  • 2Fedi P,Bafico A,Nieto Soria A. Isolation and biochemical characterization of the human Dkk-1 homologue,a novel inhibitor of mammalian Wnt signaling[J].Journal of Biological Chemistry,1999,(27):19465-19472.
  • 3Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators[J].Oncogene,2006,(57):7469-7481.doi:10.1038/sj.onc.1210054.
  • 4Yu B,Yang X,Xu Y. Elevated expression of DKKl is associated with cytoplasmic/nuclearbeta-catenin accumulation and poor prognosis jn hepatocellular carcinomas[J].Journal of Hepatology,2009,(05):948-957.doi:10.1016/j.jhep.2008.11.020.
  • 5Sheng SL,Huang G,Yu B. Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer[J].Clinical Chemistry,2009,(09):1656-1664.doi:10.1373/clinchem.2009.125641.
  • 6Kawano Y,Kypta R. Secreted antagonists of the Wnt signalling pathway[J].Journal of Cell Science,2003,(Pt 13):2627-2634.doi:10.1242/jcs.00623.
  • 7Mikheev AM,Mikheeva SA,Liu B. A functional genomics approach for the identification of putative tumor suppressor genes:Dickkopf-1 as suppressor of HeLa cell transformation[J].Carcinogenesis,2004,(01):47-59.
  • 8Lee J,Yoon YS,Chung JH. Epigenetic silencing of the WNT antagonist DICKKOPF-1 in cervical cancer cell lines[J].Gynecologic Oncology,2008,(02):270-274.doi:10.1016/j.ygyno.2008.01.034.
  • 9Tsai JF,Jeng JE,Chuang WL. Dickkopf-1 and hepatocellular carcinoma[J].Lancet Oncology,2012,(10):e410.
  • 10Wurm FM. Production of recombinant protein therapeutics in cultivated mammalian cells[J].Nature Biotechnology,2004,(11):1393-1398.doi:10.1038/nbt1026.

引证文献2

二级引证文献3

国际检验医学杂志
2011年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部