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用于药物制剂的冷冻干燥技术及相关影响因素 被引量：17

Application of Lyophilization Technique in Pharmaceutical Preparations
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摘要 介绍冷冻干燥技术在药物制剂中的应用情况,并讨论冻干制剂的处方组成、冷冻干燥过程和贮存条件等影响其效果的几个最重要因素。 The application of the freeze drying technique in pharmaceutical preparations was introduced and several important factors which influent the freeze drying effect including preparation compositions,freeze-drying protocols and storage conditions etc were discussed.
作者 耿锟锟 熊非 朱家壁 顾宁
机构地区 中国药科大学药剂研究所 生物电子学国家重点实验室江苏省生物材料与器件重点实验室东南大学生物科学与医学工程学院
出处 《药学进展》 CAS 2011年第3期104-109,共6页 Progress in Pharmaceutical Sciences
基金 国家重点基础研究发展计划(2011CB933503) 国家自然科学基金面上项目(30970754) 国家自然科学基金青年基金(81001412)
关键词 冷冻干燥技术 药物制剂 冻干保护剂 冷冻干燥过程 lyophilization pharmaceutical preparations cryoprotectant freeze drying protocols
分类号 R94 [医药卫生—药剂学]
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参考文献35

  • 1Woolfson A D, Umrethla M L, Kett V L, et al. Freeze- dried, mueoadhesive system for vaginal delivery of the HIV miembieide, dapivirine:Optimisation by an artificial neural network [ J ]. Int J Pharm, 2010, 388 ( 1/2 ) : 136-143.
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二级参考文献16

  • 1王鸿,杨纲,梁文权.盐酸布比卡因冻干乳剂的制备[J].海峡药学,2004,16(4):21-22. 被引量：7
  • 2胡连栋,唐星,崔福德.全反式维甲酸固体脂质纳米粒的制备及体内外评价[J].药学学报,2005,40(1):71-75. 被引量：20
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共引文献20

同被引文献122

引证文献17

二级引证文献57

药学进展
2011年 第3期

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