2-氯苯氧乙酸的催化合成研究

Catalytic Synthesis of 2-Chlorophenoxyacetic Acid

利用十六烷基三甲基溴化铵催化氯乙酸和2-氯苯酚合成2-氯苯氧乙酸,十六烷基三甲基溴化铵具有较高的催化活性,可以加快合成2-氯苯氧乙酸。反应过程考察了2-氯苯酚与氯乙酸摩尔比、催化剂用量、反应时间、反应温度对产率的影响以及催化剂的重复使用性能。反应的最佳条件为:在85℃下,2-氯苯酚和氯乙酸的摩尔比为1∶4,催化剂质量为0.3g,反应时间为3.5h。此反应所得到的2-氯苯氧乙酸的产率为50.50%。该催化剂的用量很少,而且易于回收,可以重复使用。

The use of cetyltrimethylammonium bromide catalyzed chloroacetate and 2-chlorophenol synthesis of 2-chlorophenoxyacetic acid.Cetyltrimethylammonium bromide has a higher catalytic activity and can accelerate the synthesis of 2-chlorophenoxyacetic acid.The reaction is studied on 2-chlorophenol and chloroacetic acid molar ratio,catalyst amount,reaction time and temperature on yield,and the performance of repeated use of catalyst.The best reaction conditions are as follows：at 85℃,2-chlorophenol and chloroacetate molar ratio of 1∶4,catalyst weight of 0.3g,reaction time of 3.5h,which get 2-chlorophenoxyacetic acidproduction rate of 50.50%.This catalyst is characterized by small amount,easy recovery,and can be reused.