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利用母胎间基因甲基化的差异性检测母血中微量胎儿DNA方法的建立 被引量：1

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摘要 随着表观遗传学方法在无创性产前诊断中的逐步应用，第一个普通应用的胎儿表观遗传学标记低甲基化maspin基因突破了胎儿性别和基因多态性的局限，为母血中胎儿DNA应用于临床开辟了新的领域，象征着非创伤性产前诊断的研究向前迈进了一大步。
作者 王健 赵富玺 刘润花 武永明 郭俊成 穆雅琴
机构地区 山西省大同大学免疫研究所 山西省大同大学医学院外科实验室
出处 《中华围产医学杂志》 CAS 2011年第2期85-87,共3页 Chinese Journal of Perinatal Medicine
基金 国家人口计生委资助项目（[2005]11号C1-41） 山西省科技厅攻关项目（20080311072）
关键词 胎儿DNA 基因甲基化 母血 MASPIN基因 非创伤性产前诊断 无创性产前诊断 检测 异性
分类号 R714.5 [医药卫生—妇产科学]
  • 相关文献

参考文献7

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二级参考文献23

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共引文献4

同被引文献7

  • 1Hansen MH, Clausen FB, Dziegiel MH. Increased Y chromosome detection by SRY duplexing[J]. Fetal Diagn Ther,2012,31 : 185 190.
  • 2Jin S,Lin XM,Law H,et al.Further improvement in quantifying male fetal DNA in maternal plasma[J].Clin Chem,2012,58:465 468.
  • 3Bellido ML,Radpour R,Lapaire O,et aI.MALDI TOF mass array analysis of RASSF1A and SERPINB5 methylation patterns in human placenta and plasma[J].Biol Reprod,2010,82:745 750.
  • 4Zhao F,Wang J,Liu R,et al.Quantification and application of the placental epigenetic signature of the RASSF1A gene in maternal plasma[J].Prenat Diagn,2010,30:778-782.
  • 5Wright CF, Burton H.The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis[J]. Hum Reprod Update,2009,15:139-151.
  • 6Chart KC,Ding C,Gerovassili A,et al.Hypermethylated RASSF1A in maternal plasma:A universal fetal DNA marker that improves the reliability of noninvasive prenatal diagnosis[J].Clin Chem,2006,52:2211-2218.
  • 7梁宏.出生缺陷资料分析及干预措施[J].中国妇幼保健,2009,24(19):2663-2664. 被引量：9

引证文献1

中华围产医学杂志
2011年 第2期

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