左旋苯环壬酯在小鼠体内的组织分布研究

Studies on Tissue Distribution of L-phencynonate Hydrochloride in Mice

目的研究左旋苯环壬酯在小鼠体内主要脏器组织分布特征,分析是否存在药物浓度高、蓄积时间长的组织和器官,并着重考察其在药效靶器官中的分布。方法采用液相色谱串联质谱法测定组织中左旋苯环壬酯的药物浓度,分析药物在组织中的分布特征。结果小鼠口服盐酸左旋苯环壬酯后,肝、脾、肺、心在给药后5 m in浓度即达到峰值,其中肝浓度最高,为531.50 ng/g,其他组织在给药后30 m in浓度达峰,2 h后各组织的药物均降至较低水平。结论盐酸左旋苯环壬酯在小鼠体内的吸收、分布均较快,药物入血后很快分布到体内各个组织中,药物在组织中的消除也较快,没有组织蓄积现象。

Objective To study in vivo distribution behavior of L-phencynonate hydrochloride in mice.Methods The liquid chromatography/tandem mass spectrometry method was established to determine the concentration of L-phencynonate in tissues of mice.Results Following oral administration to mice,the concentration of L-phencynonate in the liver,spleen,lung and heart reached the peak in 5 minutes and in 30 minutes in the other tissues respectively.Drug concentration of L-phencynonate in the tissues decreased to a very low level in 120 minutes.Conclusion L-phencynonate can be quickly absorbed,distributed and eliminated after po administration to mice and no concentration cumulation is observed in the tissues.