CA125和CA199联合检测对卵巢癌诊断价值的研究

The study on the value of the diagnose ovary cancer by joint detecting CA125 and CA199

目的:探讨联合检测肿瘤标志物CA125和CA199在卵巢癌诊断、疗效及预后判断中的价值。方法:采用化学发光方法检测160例研究对象血清中CA125、CA199含量,分析两项指标单独检测与联合检测的敏感性和特异性有无统计学差异,分析两项指标与卵巢癌组织学分型、临床分期及预后的相关性。结果:卵巢癌患者CA125、CA199水平分别为(298.0±222.1)U/ml,(71.3±40.9)U/ml;卵巢良性肿瘤患者分别为(54.6±13.4)U/ml,(26.4±23.5)U/ml;健康人群分别为(10.3±5.1)U/ml,(7.1±7.9)U/ml。CA125、CA199单独及联合检测对卵巢癌诊断的敏感性和特异性差异有统计学意义;不同病理类型和不同临床分期卵巢癌患者CA125和CA199阳性率差异有统计学意义;术前、术后卵巢癌患者血清CA125、CA199阳性例数比较,差异有统计学意义(P<0.05)。结论:血清CA125、CA199联合检测可显著提高对卵巢癌检测的敏感性,可提高对不同病理类型、不同临床分期卵巢癌的阳性检出率。

Objective：To study the value of the diagnose ovary cancer by joint detecting CA125 and CA199 Methods：The level of CA125 and CA199 in the serum of 160 patients with ovary cancer were analyzed.The sensitivity and specificity of detecting alone CA125 or CA199 and detecting joint CA125 and CA199 were analyzed Results：The level of CA125 and CA199 were（298.0±222.1）U/ml and（71.3±40.9）U/ml for the patients with ovary cancer,（54.6±13.4）U/ml and（26.4±23.5）U/ml for the patients with benign tumor of ovary,（10.3±5.1）U/ml and（7.1±7.9）U/ml for the health persons.There was remarkable difference between detecting alone CA125 or CA199 and detecting joint CA125 and CA199 for the sensitivity and specificity of the ovary cancer detection.There was remarkable difference among defference pathologic types and the clinic stages for the positive detectable rates of CA125 or CA199 of the patients with ovary cancer. Conclusion：The joint detection of CA125 and CA199 can increase the sensitivity of detecting overy cancer and the positive detectable rate of ovary cancer in defference pathologic types and the clinic stages.