益气养阴复方对大鼠糖尿病模型尿微量蛋白的影响

The Experimental Study the Influence of Traditional Chinese Medicine YiQiYangYin Compound Prescription to Rats Diabetes Model of Urine Micro Protein

目的:研究中药复方对大鼠糖尿病模型尿微量蛋白的影响,探明益气养阴中药复方可能的作用机制。方法:随机取8只大鼠为对照组喂以普通饲料,其他大鼠喂以高热量饲料喂养,1个月后,高热量饲料喂养大鼠予以STZ造膜,将模型大鼠随机分为模型组、中药高剂量组、中药低剂量组,每组8只。分别给予中药高剂量组、中药低剂量组药物煎剂,每天灌胃1次,连续4周后,测定大鼠尿中微量白蛋白(mALB)、α1-微量球蛋白(α1-MG)、β2-微量球蛋白(β2-MG)及尿转铁蛋白(TRF)。结果:中药组与模型组比较(P<0.01),有显著差异,说明中药组能显著的降低大鼠糖尿病模型尿微量蛋白,对肾脏有很好的保护作用。结论:益气养阴的中药复方对糖尿病大鼠模型的肾脏有一定保护作用,其可能机制为早期降低尿中微量蛋白有关。

Objective：Research on the influence of Traditional Chinese Medicine compound prescription to treat rats diabetes model on urine micro protein,proved Yiqiyangyin possible mechanism of Chinese herbal compound prescription.Methods：8 rats randomly selected control group fed with normal diet,the other rats fed high-calorie diet,a month later,high-calorie diet to STZ rats made film,the rats were randomly divided into model group,high group,herbal low group,n=8.High group were given herbal medicine,Traditional Chinese Medicine decoction of the low group of drugs,administered once daily for 4 weeks,measured in rat urine microalbumin（mALB）,α1-micro globulin（α1-MG）,β2-micro globulin（β2-MG）and urinary transferrin（TRF）.Results：Chinese Medicine group and model group（P0.01）,there are significant differences,indicating the medicines could significantly reduce urine protein in diabetic rats,the kidney had a good protective effect.Conclusions：Yiqiyangyin Herbs on the kidney of diabetic rats have some protective effect,the possible mechanism is to decrease urinary trace protein on the early stage.