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中心体蛋白Nlp在宫颈癌中的表达及意义 被引量：2

Expression of Centrosomal Protein Nlp in Cervical Cancer and its Significance
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摘要 [目的]探讨宫颈癌中中心体蛋白Nlp的表达情况及意义。[方法]采用免疫组化法和逆转录聚合酶链反应(RT-PCR)检测并比较28例宫颈癌组织及18例正常宫颈组织中Nlp的表达情况,并分析Nlp表达与宫颈癌临床分期及分化程度的关系。[结果]42.9%(12/28)的宫颈癌细胞核旁和/或胞浆部位Nlp呈阳性表达,正常宫颈组织均不表达Nlp(P>0.05),宫颈癌组织中Nlp的阳性表达在不同临床期别和不同分化程度组中无统计学差异(P>0.05)。RT-PCR结果显示Nlp宫颈癌组织中的表达水平明显高于正常宫颈组织。Nlp表达阳性和表达阴性者中位生存时间分别为34个月和38个月。[结论]宫颈癌组织中Nlp在蛋白水平、mRNA水平都存在高表达。
作者 马莹 白萍 宋咏梅 詹启敏
机构地区 首都医科大学附属北京妇产医院 中国医学科学院中国协和医科大学肿瘤医院肿瘤研究所
出处 《肿瘤学杂志》 CAS 2011年第2期90-92,共3页 Journal of Chinese Oncology
关键词 宫颈肿瘤 中心体 NLP
分类号 R737.33 [医药卫生—肿瘤]
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参考文献10

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共引文献1

同被引文献33

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引证文献2

肿瘤学杂志
2011年 第2期

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