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果蝇幼虫巨大致死性基因lgl及其人源同系物Hugl-1的表达及与肿瘤的关系研究进展

Research Progress in Relationship of Lethal Giant Larvae and Human Lethal-Giant-Larvae 1 with Tumour
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摘要 果蝇幼虫巨大致死性基因lgl是果蝇体内第一个被报道的抑癌基因,具有进化的保守性,其人源性同系物Hugl-1的表达现有研究表明与多种肿瘤的发生、发展及转移密切相关。全文就lgl及Hugl-1的结构、功能、可能的调节机制及其与肿瘤的关系作一综述。
机构地区 浙江省肿瘤医院
出处 《肿瘤学杂志》 CAS 2011年第2期143-146,共4页 Journal of Chinese Oncology
基金 2008年浙江中医药大学科研基金
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