阿莫西林-舒巴坦联用替硝唑相关中性粒细胞减少

Neutropenia due to concomitant use of amoxicillin/sulbactam and tinidazole

1例76岁男性患者,因丹毒给予阿莫西林-舒巴坦2.25 g溶于0.9%氯化钠注射液100 ml,2次/d静脉滴注;0.4%替硝唑100 ml,1次/d静脉滴注。6 d后血常规检查:白细胞计数1.86×109/L,中性粒细胞0.21,淋巴细胞0.55,单核细胞0.23,中性粒细胞计数0.39×109/L。立即停用阿莫西林-舒巴坦和替硝唑,并给予对症治疗。停药3 d后,血常规检查:白细胞计数3.20×109/L,中性粒细胞0.32,淋巴细胞0.54,单核细胞0.12,中性粒细胞计数1.04×109/L。

A 76-year-old male patient with erysipelas received an IV infusion of amoxicillin/sulbactam 2.25 g in 0.9% sodium chloride 100 ml twice daily and an IV infusion of 0.4% tinidazole 100 ml once daily.Six days later,his routine blood tests revealed the following results： WBC count 1.86×10^9/L with neutrophils 0.21,lymphocytes 0.55,and monocytes 0.23,and neutrophil count 0.39×10^9/L.Amoxicillin/sulbactam and tinidazole were withdrawn immediately and he received symptomatic treatment.Three days after drug discontinuation,routine blood tests showed a WBC count of 3.20×10^9/L with neutrophils 0.32,lymphocytes 0.54,and monocytes 0.12,and a neutrophil count of 1.04×10^9/L.