盐酸氨溴索葡萄糖注射液致过敏性休克

Ambroxol hydrochloride glucose injection-induced anaphylactic shock

1例75岁男性患者因肺部感染给予静脉滴注盐酸氨溴索葡萄糖注射液50 ml(含盐酸氨溴索30 mg及葡萄糖2.5 g)。约30 min后,患者突发胸闷、冷汗、恶心、头晕。体格检查:血压40/0 mm Hg(1 mmHg=0.133 kPa),口唇发绀,面色苍白,四肢冷,意识模糊。立即停止静脉滴注,行心电监护,并给予吸氧及地塞米松、异丙嗪、多巴胺等药物治疗。4 h后患者血压平稳,130/70 mm Hg,其余生命体征正常,症状消失。住院2周期间,未再静脉滴注盐酸氨溴索葡萄糖注射液,未再发生类似反应。

A 75-year-old man received an IV infusion of ambroxol hydrochloride glucose injection 50 ml（containing ambroxol hydrochloride 30 mg and glucose 2.5 g） for pulmonary infection.About 30 minutes later,the patient abruptly experienced chest distress,cold sweat,nausea,and dizziness.Physical examination showed a blood pressure of 40/0 mm Hg,cyanosis,pale face,cold extremities,and confusion.The intravenous infusion was stopped immediately.He underwent electrocardiogram monitoring and received oxygen inhalation therapy,dexamethasone,promethazine,and dopamine.His blood pressure became stable and was 130/70 mm Hg 4 hours later.His other vital signs were normal,and his symptoms disappeared.During a two-week hospitalization,intravenous infusion of ambroxol hydrochloride was not readministered and similar symptoms did not recur.