克林霉素致昏迷

Clindamycin-induced coma

1例53岁男性患者,因咽炎给予克林霉素600 mg溶入0.9%氯化钠注射液250 ml静脉滴注。滴注结束时,患者突然昏迷,呼之不应,呼吸12次/min,双侧瞳孔对光反射消失。给予吸氧、补液治疗1 h后仍呈深昏迷状态。分别给予甘露醇、呋塞米、纳洛酮、葛根素、奥扎格雷钠等静脉滴注,治疗约12 h患者清醒,治疗约15 h时突然出现狂躁,给予氟哌啶醇5 mg肌内注射。治疗约20 h患者精神状态基本恢复正常。

A 53-year-old male patient with pharyngitis was given an IV infusion of clindamycin 600 mg dissolved in 0.9% sodium chloride 250 ml.After infusion completion,the patient developed a coma and unresponsiveness to verbal stimuli.His respiratory rate was 12 breaths/min and his pupils showed no light reflex.He received oxygen inhalation therapy and fluid supplement and,one hour later,he remained in a deep coma.The patient was treated with mannitol,furosemide,naloxone,puerarin and sodium ozagrel by intravenous infusions,respectively.After about 12 hours of treatment,the patient regained consciousness and,after about 15 hours of treatment,he suddenly presented with mania.IM haloperidol 5 mg was given.After about 20 hours of treatment,his mental condition basically returned to normal.