急性脑出血患者血清VEGF的动态变化

The dynamic changes of serum VEGF in the patients with acute intracerebral hemorrhage

目的 通过对急性脑出血患者血清中血管内皮生长因子（VEGF）在发病后不同时程的含量进行监测,研究其动态变化.探讨其在脑出血后脑损伤和修复中的作用.方法 56例急性脑出血患者,分别于发病后1,2,3,7,14d各采血1次,收集血清.正常对照组12例亦取静脉血.应用双抗体夹心ELISA法进行血清VEGF含量检测.结果 脑出血组不同时程VEGF平均水平均高于正常对照组（P〈0.01）.VEGF浓度于发病1 d内开始升高,2,3 d继续升高,7 d达高峰,随后下降,14 d仍高于正常.结论 脑出血组不同时程VEGF平均水平均高于对照组,且呈动态变化.提示VEGF在脑出血后脑组织继发性损伤和修复过程中发挥作用.

Objective To investigate the role of VEGF in brain injury and recovery after cerebral hemorrhage by observing the dynamic changes of VEGF levels in the patients with acute intraeerebral hemorrhage during different phases. Methods Venous blood samples were collected from 56 patients with acute intracerebral hemorrhage during different time course after the onset of the disease（within 24, 48 hrs,and at 3,7 and 14 days）, and 12 healthy controls. Serum VEGF level was determined by ELISA. Results The level of VEGF in the patients with acute intracerebral hemorrhage was much higher than that in control group （P 〈 0. 001）. The levels of serum VEGF gradually increased after the onset of acute intracerebral hemorrhage and reached the peak at day 7,and maintained at day 14. Conclusions The plasma level of VEGF from the patients with acute intracerebral hemorrhage was much higher than that in control group and showed dynamic changes during different phases, suggesting VEGF participating in the process of pathological change after cerebral hemorrhage therefore played a role in brain injury and recovery.