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成年海马神经再生与抑郁

Adult ippocampal neurogenesis and depression
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摘要 重症抑郁是一种严重的精神障碍,其终生患病率超过15%,主要的行为变化是情绪低落、消极观念、无助、活力和注意力下降,自杀比例约15%,是全球第四大致残因素。尽管抑郁症从症状到流行病学情况都十分严重,但对此病的有效干预仍显不足,而进一步揭示抑郁症病理、生理学面临巨大的挑战,究其原因为:(1)综合征分类法及病因学的多样性;(2)内疚,自杀等综合征在实验动物中难以模拟。
出处 《神经疾病与精神卫生》 2011年第1期79-82,共4页 Journal of Neuroscience and Mental Health
关键词 海马 神经再生 抑郁 Hippocamp Neurogenesis Depression
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参考文献33

  • 1Maes M, Yirmyia R, Noraberg J, et al. The inflammatory and neurodegenerative (I&-ND) hypothesis of depression: leads for future research and new drug developments in depression[J]. Metab Brain Dis,2009,24(1) :27-53.
  • 2Vaishnav Krishnan,Eric J. Nestler. "The molecular neurobiology of depression[J]. Nature,2008,455(10):894-902.
  • 3Darrick T Balu, Irwin Lucki. Adult hippocampal neurogenesis: Regulation, functional implications, and contribution to disease pathology[J]. Neuroscience and Biobehavioral Reviews, 2009, 33 (3) : 232-252.
  • 4John G. Nicholls, A. Robert Martin, Bruce G. Wallace, et al. From Neuron to Brain(M)rM3. Fourth Edition,Sinauer Asso- ciates,Inc, 2002 : 633-647.
  • 5Shors TJ ,Townsend DA, Zhao M, et al. Neurogenesis may re- late to some but not all types of hippocampal- dependent learning[J]. Hippocampus, 2002,12 (5) : 578-584.
  • 6Shors TJ, Miesegaes G, Beylin A, et al. Neurogenesis in the a- dult is involved in the formation of trace memories[J]. Na- ture,2001,410(3) ;372-376.
  • 7Austin MP,Mitchell P,Goodwin GM. Cognitive deficits in de- pression: possible implications for functional neuropathology [J]. Br. J. Psychiatry,2001,178:200-206.
  • 8Fossati P,Coyette F,Ergis AM,et al. Influence of age and ex- ecutive functioning on verbal memory of inpatients with de pression[J]. Affect Disord,2002,68(2) ;261-271.
  • 9Sheline YI,Gado MH.,Kraemer HC. Untreated depression and hippocampal volume loss[J]. Am J Psychiatry,2003,160(8): 1 516-1 518.
  • 10Sapolsky RM. Is impaired neurogenesis relevant to the affec- tive symptoms of depression? [J]. BiolPsychiatry, 2004, 56 (3) : 137-149.

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