摘要
目的:探讨艾司西酞普兰治疗老年抑郁症的疗效及安全性。方法:将56例老年抑郁症患者随机分为两组各28例,研究组口服艾司西酞普兰治疗,对照组口服文拉法辛治疗,观察6周。于治疗前及治疗12、4、6、周末采用汉密顿抑郁量表(HAMD)评定临床疗效,副反应量表(TESS)评定不良反应。结果:治疗6w末,研究组总有效率92.85%,对照组为85.78%,两组总体疗效相当(χ2=0.187,P>0.05)。汉密顿抑郁量表评分,两组治疗1周末起,较治疗前有显著下降(P<0.05或0.01),研究组治疗1周末较对照组下降显著(P<0.05),其他时点评分均无显著性差异(P>0.05),两组不良反应均轻微。结论:艾司西酞普兰治疗老年抑郁症的疗效与文拉法辛相当,且起效较文拉法辛快,安全性高,依从性好。
Objective：To explore the efficacy and safety of Escitalopram in the treatment of elderly patients with depression.Methods：56 patients were randomly divided into research group（n=28） took orally escitalopram and control group（n=28） did venlafaxine for 6 weeks.Efficacies were assessed with the Hamilton Depression Scale（HAMD） and adverse reactions with the Treatment Emergent Symptom Scale（TESS） before treatment and at the ends of the 1st,2nd,4th,and 6th week.Results：After 6 week treatment,total effective rates were respectively 92.85% in the research and 85.78% in the control group,the total efficacies of both groups were equivalence（P 0.05）.The HAMD scores lowered more significantly since the end of the 1st week in both groups（P 0.05 or 0.01）,did more significantly in the research than in the control group at the end of the 1st week（P 0.05）,and there were no significant differences at other time points（P 0.05）.Adverse reactions of both groups were mild.Conclusion：Escitalopram has therapeutic equivalence to Venlafaxine,but takes effects quicker and has higher safety and better compliance in the treatment of elderly depression,and deserves to be extended and utilized clinically.
出处
《中国民康医学》
2011年第6期664-665,共2页
Medical Journal of Chinese People’s Health
