阿托伐他汀钙联合普罗布考对不稳定型心绞痛患者氧化修饰低密度脂蛋白及高敏C反应蛋白的影响

Effect of combined atorvastatin with probucol on the bleed level of ox-LDL and hs-CRP in unstable angina pectoris patients

目的 观察阿托伐他汀钙联合普罗布考对不稳定型心绞痛患者氧化修饰低密度脂蛋白（ox-LDL）及高敏C反应蛋白（118-CRP）的影响.方法 150例不稳定型心绞痛患者随机分成对照组、阿托伐他汀钙组（他汀组）和阿托伐他汀钙及普罗布考联合治疗组（联合治疗组）,共观察1个月.分别于治疗前后检测患者血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、ox-LDL和hs-CRP水平.结果 治疗前联合治疗组的TC、TG、LDL-C和OX-LDL、hs-CRP值分别为（5.56±1.28）、（2.81±0.79）、（3.34±0.83）mmol/L和（0.84±0.13）、（12.24±5.63）mg/L,与对照组和他汀组比较差异无统计学意义（P＞0.05）.治疗后联合治疗组的TC、TG、LDL-C和ox-LDL、hs-CRP值分别下降至（3.16±0.22）、（1.46±0.62）、（1.71±0.69）mmol/L和（0.41±0.08）、（1.40±3.57）mg/L,与治疗前比较显著下降（P＜0.01）,与对照组比较显著下降（P＜0.01）且较他汀组显著下降（P＜0.05）.结论 阿托伐他汀钙联合普罗布考治疗较阿托伐他汀钙单药能更进一步降低不稳定型心绞痛患者血脂及炎症反应,从而更有效地稳定斑块.

Objective To observe the effect of combined atorvastatin with probucol on the blood level of oxidized low density lipoprotein （ox-LDL） and high-sensitive C reaction protein （hs-CRP） in patients with unsta- ble angina pectoris. Methods 150 diagnosed patients were randomly divided into controlled, atorvastatin and combined group. Blood total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL）, low density lipoprotein cholesterol （LDL）, ox-LDL and hs-CRP were detected before and after treatment in all pa- tients of these three groups. Results In the combined group, the blood level of TC, TG, LDL, ox-LDL, hs- CRP before treatment was 5.56±1.28, 2.81±0.79, 3.34±0.83, 0.84±0.13, 12.24±5.63 respectively, no significant difference as compared with the other two goups （P〉0.05）. After treatment, the blood level of TC, TG, LDL, ox- LDL, hs-CRP dropped to 3.16±0.22, 1.46±0.62, 1.71±0.69, 0.41±0.08, 1.40±3.57 respectively. The decrease was significant as compared with the level before treatment （P〈0.01） and to the atorvastatin （P〈0.05） and the controlled group （P〈0.01）. Conclusion The combination of atorvastatin with probucol shows a better effect on lowering blood-lipid and extenuating inflammatory reaction, and so further stabilize the plaque of atherosclerosis.