血尿酸水平与冠心病心功能不全关系的研究

The relationship between serum uric acid and heart function in patients with coronary heart disease

目的 检测冠心病心功能不全患者的血尿酸水平,研究二者在疾病发生发展过程中的关系.方法 将冠心病患者分为两组：心功能正常组215例,心功能不全组131例,心功能不全组按纽约心脏病学会NYHA分Ⅱ～Ⅳ级.应用尿酸氧化酶法测定空腹血尿酸浓度,并通过统计学方法分析患者心功能程度与血尿酸浓度的关系.结果 ①心功能不全组血尿酸浓度为（410.87±108.30）μmol/L,高尿酸血症发生率为46.15%;心功能正常组血尿酸浓度为（331.82±90.06）μmol/L,高尿酸血症发生率为15.20%,两组比较P＜0.01.②心功能不全Ⅱ级组血尿酸浓度为（376.47±105.07）μmol/L,高尿酸血症发生率为25.00%;心功能不全Ⅲ级组血尿酸浓度为（396.52±104.89）μmol/L,高尿酸血症发生率为34.21%;心功能不全Ⅳ级组血尿酸浓度为（436.13±107.22）μmol/l,高尿酸血症发生率为63.64%.结论 冠心病心功能不全者血尿酸水平升高,随着心功能的下降血尿酸水平升高,高尿酸血症发生率增加,血尿酸浓度高低与心功能不全严重程度呈正相关.

Objective To analyze the level of serum uric acid and the relationship with coronary heart disease （CHD）. Methods Patients with CHD were divided into 2 groups： cardiac dysfunction group（ 131cases ） and normal cardiac function group（ 131 cases）. The level of SUA was measured with urate oxidase method, and the relationship between SUA level and cardiac function severity was analyzed by statistic way. Results （1）The mean SUA level in cardiac dysfunction group was （410.87±108.30）μmol/L, and the total incidence of hyperuricemia （HUA） was 46.15%. The mean SUA level in normal cardiac function group was （331.82±90.06）μmol/L,and the total incidence of HUA was 15.20%. （2）The mean SUA levels in patients with NYHA Ⅱ , NYHAⅢand NYHAⅣ were （66.47±105.07）μmol/L, （396.52±104.89）μmol/L and （436.13±107.22）μmol/L respectively, and the total incidence of HUA was 25.00%, 34.21% and 63.64% respectively. Conclusion The mean SUA level in patients with cardiac dysfunction is higher than patients with normal cardiac funtion group. With the decline of cardiac function, the mean SUA level elevated, and the total incidence of HUA elevated too. There is a positive eorrelation between the level of SUA and the severity of cardiac dysfunction.