胺碘酮和心律平治疗心力衰竭并室性心律失常的对比观察

Analysis effect of amiodarone,and propafenone on patients with heart failure and ventricular arrhythmia

目的 分析对比观察胺碘酮、心律平治疗充血性心力衰竭合并室性心律失常的临床疗效与安全性.方法 80例充血性心力衰竭合并室性心律失常的患者分成两组,每组各40例.两组患者抗心力衰竭治疗相同,观察组应用胺碘酮抗心律失常,对照组应用心律平抗心律失常,疗程4周,观察临床疗效、室性心律失常及左心室射血分数（LVEF）的变化,并对结果进行回顾性分析.结果 治疗后观察组临床疗效高于对照组（P＜0.01）,室性心律失常减少高于对照组（P＜0.05）,LVEF值增加优于对照组（P＜0.05）.对照组有6例出现新的心律失常,停用心律平后恢复.结论 充血性心力衰竭合并室性心律失常必须长期使用抗心律失常药物时,应首选胺碘酮治疗而不宜使用心律平.

Objective To compare and observe effect and safety of arniodarone, and propafenone on patients with heart failure and ventricular arrhythmia. Methods 80 patients with heart failure and ventricular arrhythmia were divided into two groups, each 40 respectively. Both groups with same anti-heart failure therapy, administrating amiodarone in the therapy group, propafenone in the control group, and reviewing analysis effect observe clinic effect, ventricular arrhythmia, left ventrieular ejection fraction. Results Clinic effect of therapy group was better than that of control group （P〈0.01）, ventrieular arrhythmia in therapy group decreased than con- trol group （P〈0.05）, LVEF increased than control group （P〈0.05）. And 6 patients in control group showed new cardiac arrhythmia and recovered when discontinuing propafenone. Conclusion When patients with heart failure and ventrieular arrhythmia must administrate anti-arrhythmia medications, amiodarone should be chosen rather than propafenone.