中药对造影剂肾病防治作用探讨

The study on traditional Chinese medicine preventing contrast-induced nephropathy after interventional therapy

目的探讨中药对冠状动脉介入治疗术(PCI)患者造影剂肾病(contrast-induced nephropathy,CIN)的防治作用。方法选择360例接受PCI治疗的患者,随机分为充分水化治疗组、中药组与常规治疗组,检测所有患者PCI术前以及术后第2、3天的血肌酐水平。结果 360例患者中15例发生CIN(4.16%),充分水化治疗组4例(3.33%),常规治疗组11例(9.17%),中药治疗组0例。充分水化治疗组发病率显著低于常规治疗组,差异有统计学意义(P<0.05)。中药治疗组CIN的发病率显著低于充分水化治疗组,差异有统计学意义(P<0.05)。结论中药能降低PCI造影患者的血肌酐水平以及造影剂肾病的发病率。

Objective To study the prevention of traditional Chinese medicine to patients with cardiovascular vesseldisease from contrast - induced nephropathy（CIN） after the interventional therapy. Methods 360 patients were randomly divided into three groups： Chinese medicine group （n = 120）, strengthened rehydration therapy group （n = 120） and the control group（ n = 120）. The treated group were received strengthened rehydration therapy through offering oral administration and intravenous fluid infusion. The serum ereatinine levels were measured before,2and3 days after percutaneous coronary intervention. Results The incidence of CIN in the treated group was significantly lower than that in the control group,but more lower in traditional Chinese medicine group. Conclusions The traditional Chinese medicine therapy can effectively prevent from contrast -induced nephropathy.