连续性血液净化对急性呼吸窘迫综合征单核细胞分泌功能和抗原呈递功能的影响

Continuous Blood Purification Influences Cytokine Secreting and Antigen Presenting Functions of Monocyte in Acute Respiratory Distress Syndrome

目的:研究连续性血液净化(CBP)对急性呼吸窘迫综合征(ARDS)患者单核细胞分泌功能和抗原呈递功能的影响。方法:动态检测36例接受CBP的ARDS患者单核细胞功能,并与健康人群进行比较。结果:ARDS患者单核细胞分泌细胞因子功能高于健康人群,而抗原呈递功能与健康人群相比无显著性差异。CBP治疗48h后,单核细胞细胞分泌功能恢复至正常水平,CBP治疗对单核细胞抗原呈递功能无显著性影响。结论:CBP治疗可降低ARDS单核细胞的细胞因子分泌功能,但对其抗原呈递功能无明显影响。

Objective： To investigate the influences of continuous blood purification （CBP） on the function of monocyte in patients with acute respiratory distress syndrome （ARDS）. Method： The function of monocyte in 36 patients with ARDS accepted CBP was dynamically observed and compared with that of healthy people. Results： Cytokine secreting function of monocyte in patients with ARDS was stronger than that in healthy people, but there was no significant difference in antigen presenting function between the two groups. 48 h after CBP treatment, cytokine secreting function declined to normal. CBP treatment did not significantly change the antigen presenting function. Conclusion： CBP corrects the disorder of cytokine secreting function of monocyte in patients with ARDS, except antigen presenting function.