急诊糖尿病酮症酸中毒患者氧化应激水平的变化

Exploration of oxidative stress in emergency patients with diabetic ketoacidosis

目的初步探讨急诊糖尿病酮症酸中毒患者体内氧化应激的变化及其意义。方法将204例入选者分为健康对照组、单纯糖尿病组、慢性并发症组和酮症酸中毒组，分别测定总超氧化物岐化酶（T—SOD），活力、丙二醛（MDA）含量和总抗氧化力（T—AOC）。结果与对照组相比较，单纯糖尿病组、慢性并发症组和酮症酸中毒组T—SOD活力和T—AOC明显降低（P〈0．01），MDA含量明显升高（P〈0．01）。与单纯糖尿病组、慢性并发症组相比，酮症酸中毒组T—SOD活力和T—AOC明显降低（P〈0．01），MDA含量明显升高（P〈0．01）。结论急诊糖尿病酮症酸中毒患者较无并发症或慢性并发症的糖尿病患者具有更高的氧化应激水平。

Objective To explore the levels of oxidative stress in emergency patients with diabetic ketoacidosis. Methods 204 subjects were divided into four groups, healthy control group, simplex diabetes mellitus （DM） group, DM with chronic complications group, and diabetic ketoacidosis （DKA） group. Total Superoxide Dismutase （T-SOD） activity, Malondialdehyde （MDA） content and Total Anti-oxidation Capacity （T-AOC） were examined respectively in all four groups. Results T-SOD activity and T-AOC in simplex DM group, chronic complications group and DKA group were significantly lower and MDA content significantly higher than those indicators in the healthy control group （P〈0.01）. Moreover, T-SOD activity and T-AOC in DKA group were significantly lower and MDA content significantly higher than those in simplex DM group and chronic complications group （P〈0.01）. Conclusion The oxidative stress levels in emergency patients with DKA were higher than other DM patients without complications or chronic complications.