吸入M_3受体拮抗剂对稳定期COPD肺功能的影响

Effect of M_3 Receptor Antagonist on Lung Function in Stable COPD

目的:评价噻托溴铵干粉剂对中、重度稳定期慢性阻塞性肺疾病(COPD)患者肺功能的影响。方法:采用随机对照研究140例COPD患者,噻托溴铵组使用噻托溴铵干粉剂,对照组使用氨茶碱片,总观察时间12周,治疗前后测定肺功能。结果:治疗后噻托溴铵组深吸气量、第1秒用力肺活量和用力肺活量明显改善,分别增加了102mL,256mL和154mL,对照组改善不明显,仅分别增加了10mL,08mL,15mL。结论:噻托溴铵能改善中、重度稳定期COPD患者的肺功能,可提高患者的生活质量。

Objective：To research the effect of M3 receptor antagonist（tiotropium） on lung function in stably moderate and severe chronic obstructive pulmonary disease（COPD）.Methods：A randomized controlled clinical trail was conducted in 140 patients with COPD.80 patients were treated by tiotropium（18μg,qd inhaled） and 60 patients were treated by placebo for aminophylline 12 weeks.Results：Tiotropium provided significantly improvement in inspiratory capacity（IC）,forced expiratory volume in one second（FEV1） and forced vital capacity（FVC） than baseline,IC,FEV1 and FVC in tiotropium group was increased 102mL,256 mL and 154 mL respectively,and it was significantly higher than that aminophylline group（10 mL,08mL and 15 mL respectively）.Conclusion：Tiotropium was an effective bronchodaliator on improving lung function and health status in patients with stably moderate and severe COPD.