HDAC1蛋白在乳腺癌中的表达及临床意义及与ER、PR的关系

Expression of histone deacetylase1 in breast carcinoma and its clinical significance

目的:探讨乳腺癌组织中组蛋白去乙酰化酶1(HDAC1)的表达及临床意义。方法:应用免疫组织化学SP法检测78例乳腺癌组织和20例癌旁组织中HDAC1蛋白的表达情况并分析其与ER、PR之间的关系。结果:(1)HDAC1蛋白在78例乳腺癌中的阳性表达率为78.2%(61/78),在癌旁组织中的阳性表达率为5%(1/20),两组差异有统计学意义(P<0.01)(2)乳腺癌组织中的HDAC1蛋白在ER或PR阴性乳腺癌组织中的表达分别高于其在ER或PR阳性乳腺癌组织中的表达(P<0.01)结论:乳腺癌组织中的HDAC1蛋白过度表达与肿瘤发生发展密切相关。

To investigate the expressions of HDAC1 protein and its clinical significance in the breast carcinoma tissue.Methods：The expression of HDAC1 protein was determined by immunohistochemistry with SP system.Its correlation to estrogen receptor（ER） and progesterone receptor（PR） was analyzed.Results：（1）The positive rate of HDAC1 protein was 78.2% in breast carcinoma,which was 5% in noncancerous tissue group.There were significant differences between them（P0.01）.（2）The expression of HDAC1 had negative correlation to ER and PR.Conclusion：The overexpression of HDAC1 protein closely correlated with the tumor carcinogenesis.