血清视黄醇结合蛋白4与慢性乙肝的相关性分析

Relationship between Serum Retinol-Binding Protein4 and Chronic Hepatitis B

目的:观察慢性乙肝患者血清视黄醇结合蛋白4(RBP4)、前白蛋白(PA)、血氨水平,分析RBP4与慢性乙肝的相关性。方法:采集90例慢性乙肝患者分为轻度组26例,中度组34例,重度组30例,另选择30例健康对照组。采用酶联免疫吸附法(ELISA)测定血清RBP4水平,采用免疫透射比浊法测定血清PA水平,用全自动生化分析仪测定血氨水平。结果:血清RBP4、PA在病例组中低于对照组,差异有统计学意义(P<0.05),血氨水平在病例组中高于对照组,差异有统计学意义(P<0.05)。血清RBP4、PA、血氨水平在轻度、中度、重度组内比较P<0.05,有统计学意义。经Pearson's相关分析,血清RBP4与PA浓度呈显著正相关相关(r=0.896,P<0.01),与血氨浓度呈显著负相关(r=-0.781,P<0.01)。结论:RBP4与慢性乙肝存在一定的相关性,与肝脏的损伤程度有关,可作为预测肝脏损伤的血清标志物。

Objective：To evaluate the correlation of Retinol binding protein 4（RBP4） and the Chronic Hepatitis B by test the serum level of the RBP4,the prealbumin（PA） and the blood ammonia（BA）.Methods：Ninety patients with Chronic Hepatitis B were divided into the mild group（n=26）,the moderate group（n =34） and the severe group（n=30）,30 normal subjects without the Hepatitis B diagnosed by the laboratory examination served as the control group.The serum level of RBP4 is measured by enzyme linked immune sorbent assay（ELISA）,while the PA is measured by turbidmetric immunoassay and the serum level of the BA is measured by the auto-matic biochemistry analyzer.Results：The serum level of RBP4 and PA were lower in the research group than the control group（P0.05）,but the blood ammonia is higher in the research group than the control group（P0.05）.The mean levels of RBP4、PA and BA among the mild,moderate and the severe group were significantly different（P0.05）.The serum level of RBP4 was significantly positive correla-tion with the PA（r=0.896,P0.01）,but it was apparently negative correlation with the blood ammonia in Spearman correlation coeffi-cients（r=-0.781,P0.01）.Conclusions：RBP4 may act as one predictor of hepatic injury,and be correlated with the Chronic Hepatitis B.