蔗糖铁注射液治疗老年缺铁性贫血疗效观察

Clinical observation of iron sucrose injection in treating old patients with iron deficiency anemia

目的观察蔗糖铁注射液治疗老年缺铁性贫血（IDA）的疗效和不良反应。方法选择32例老年IDA患者，按随机数字表法分为静脉组（17例）和口服组（15例），观察两种方法对改善贫血的疗效和不良反应。结果治疗后静脉组及口服组血红蛋白（1ib）均较治疗前升高，分别为（100．18±8．71）g，L和（85．80±6．92）g/L，两组比较差异有统计学意义（P〈0．01）；治疗后血清铁亦有上升，两组分别为（23．84±5．34）μmol／L和（14．63±3．29）μmol／L，与治疗前比较差异有统计学意义（P〈0．01）。静脉组无明显不良反应发生，口服组有6例（40％）发生胃肠道反应。结论静脉用蔗糖铁可作为老年IDA患者补铁方式，疗效优于口服铁剂，且不良反应发生率低。

Objective To observe the effect and adverse reactions of iron sucrose injection in treating old patients with iron deficiency anemia （IDA）. Methods Thirty-two old patients with IDA were divided into injection group （17 patients） and oral group（ 15 patients） by random digits table. The effects of improvemeht on IDA and their adverse reactions were observed. Results After treatment, hemoglobin （Hb） in the injection group and oral group was （ 100.18 ± 8.71 ） g/L and （85.80 ± 6.92）g/L（P 〈 0.01 ）, and serum iron was （23.84 ±5.34） μmol/L and （ 14.63 ± 3.29） μmol/L （P 〈 0.01 ）. There were no obvious adverse reactions in injection group, whereas there were 6 cases（40% ） with gastric and colon adverse reaction in oral group. Conclusions The treatment of intravenous injection of iron sucrose can be effectively used to cure old patients with IDA. It has better effect and has lower rate of adverse reaction.