奥曲肽治疗肠梗阻临床疗效观察

Clinical efficacy of bowel obstruction treated by octreotide

目的 观察奥曲肽（善宁）治疗肠梗阻的临床疗效.方法 将95例肠梗阻患者按随机数字表法分为研究组（48例）和对照组（47例）.对照组给予禁食、胃肠减压、全肠外营养支持、充分补液、维持水电解质代谢和酸碱平衡以及抗生素预防感染等常规治疗,研究组在常规治疗的基础上加用善宁0.1 mg进行皮下注射,观察并比较两组患者的临床症状缓解时间、胃肠减压量、肛门排气时间以及住院时间,同时比较两组的有效率.结果 研究组临床症状缓解时间、胃肠减压量、肛门排气时间、住院时间均明显少于对照组,差异均有统计学意义（P＜0.05）;研究组有效率为97.9%（47/48）,对照组为87.2%（41/47）,两组比较差异有统计学意义（P＜0.05）;研究组均未发生明显不良反应.两组治疗无效者均中转手术处理.结论 善宁治疗肠梗阻疗效可靠,不良反应轻,值得临床推广应用.

Objective To observe the clinical efficacy of octreotide for treatment of bowel obstruction. Methods Ninety-five cases of bowel obstruction treated from January 2007 to July 2010 were divided into study group （48 cases） and control group （47 cases） by random digits table. Patients in control group received the conventional therapy including fasting, gastrointestinal decompression, total parenteral nutrition, sufficient fluid infusion, water-electrolyte and acetic-alkali equilibrium maintenance and infection prevention, while patients in study group received octreotide 0.1 mg by subcutaneous injection on the base of above conventional therapy, the clinical symptomatic relief time, gastrointestinal decompression volume,anus exhaust time, hospitalization time and effective power of both groups were observed and compared.Results The clinical symptomatic relief time, gastrointestinal decompression volume, anus exhaust time and hospitalization time in study group were all significantly lower than those in control group, the differences was statistically significant （P 〈 0.05）; the effective power in study group was 97.9%（47/48）,which was significantly higher than that in control group（87.2% ,41/47）, the difference was statistically significant（P 〈0.05）. There was no obvious adverse reactions occurred, the patients of treatment futility were therapied by surgery later. Conclusion Octreotide used to treat bowel obstruction has a reliable efficacy with low reverse reaction and deserves general application.