儿童青少年垂体柄中断综合征的鞍区磁共振影像特征

Magnetic Resonance Image of Sellar Region in Pituitary Stalk Interruption Syndrome in Children and Adolescents

目的探讨儿童青少年垂体柄中断综合征（PSIS）的鞍区磁共振成像（MRI）特征。方法选取2001年2月至2010年8月在北京协和医院诊断的31例PSIS患者,采集MRI影像学资料测量垂体的高径、横径、前后径,计算垂体体积和冠状面面积,结合患者临床资料进行回顾性分析。结果本组患者中男性28例,女性3例,平均年龄（16.5±3.8）岁（6~25岁）。MRI图像显示16例患者为垂体柄断裂伴垂体后叶异位,15例为垂体柄明显变细或者显示不清,其中7例为空泡蝶鞍。所有31例PSIS患者均显示垂体体积缩小,临床上均出现垂体前叶功能减退的症状。结论 PSIS的MRI图像特征为垂体柄断裂并伴有垂体后叶异位或者垂体柄明显变细或显示不清,并有垂体前叶多种激素缺乏。

Objective To investigate the magnetic resonance imaging（MRI） manifestations of sellar region of children and adolescents with pituitary stalk interruption syndrome（PSIS）.Methods Thirty-one PSIS cases were selected from February 2001 to August 2010 in Peking Union Medical College Hospital.MRI images were collected to calculate the volume and coronary area of the pituitary based on its measured height,width,and anteroposterior diameter.The results of the measurement were retrospectively analyzed together withclinical data.Results The patients in this study included 28 males and 3 females,aged 16.5±3.8 years（range,6-25 years）.MRI images showed pituitary stalk rupture associated with ectopic posterior pituitary in 16 cases,significantly thinner or unclear pituitary stalk in 15 cases,in which 7 cases were found with vacuole turcica.All the 31 patients presented with reduced pituitary volume and dysfunction of anterior pituitary.Conclusion PSIS may show pituitary stalk interruption with ectopic posterior,thinning or unclear of pituitary stalk,and with a variety of anterior pituitary hormone deficiency.