四川彝族麻风易感性和HLA-DRB1和HLA-DQB1等位基因的相关性研究

Study on the association between HLA - DRB1 and HLA - DQB1 loci, and leprosy susceptibility in Yi nationality, Sichuan Province, China

目的:分析四川省彝族人群HLA-DRB1、HLA-DQB1等位基因与麻风的相关性。方法:运用聚合酶链反应-序列特异性引物(PCR-SSP)方法,对四川省彝族100例麻风患者和100例健康对照分别进行HLA-DRB1和HLA-DQB1等位基因检测,并比较病例组和对照组之间等位基因频率的差异。结果:麻风病例组HLA-DRB1*13等位基因频率较对照组显著增高(P<0.05)。结论:HLA-DRB1*13可能与四川省彝族麻风的易感性相关。

Objective： To analyze the assoeiation of the HLA - DRB1 and HLA- DQB1 loci with leprosy susceptibility in Yi nationality, Sichuan Province, China. Methods： Polymerase chain reaction - sequence specific primers （PCR- SSP） was used to genotype HLA- DRB1 and HLA- DQB1 alleles in 100 patients and 100 healthy controls. Results： The frequency of allele HL4 - DRB1＊- 13 was significantly higher in leprosy patients than lhat in normal controls. Conclusion： HLA - DRB1＊ 13 may be related to leprosy susceptibility in Chinese Yi nationality.