抗抑郁剂对伴有失语的脑卒中患者神经功能康复的影响

Effects of antidepressants on neurofunctional recovery of post-stroke patients with aphasia

[目的]观察治疗性应用抗抑郁剂对伴有失语的脑卒中患者神经功能康复的影响。[方法]82例伴有失语的脑卒中患者随机分成两组,两组均接受相同的脑血管病治疗,治疗组在此基础上加用氟西汀治疗,对照组未应用安慰剂。应用改良爱丁堡斯堪的那维亚评分量表(MESSS)及日常生活能力量表(ADL)评定脑卒中患者治疗前、治疗中及治疗后神经功能缺损程度及日常生活能力。[结果]在治疗的第4周、第12周及随访12周时,氟西汀组患者的MESSS得分分别为14.6、10.2、8.9;ADL得分分别为34.4、27.6、28.8,与对照组的MESSS得分(17.8、14.6、13.8)、ADL得分(41.4、34.6、35.5)比较,差异均有显著性意义(P<0.01)。[结论]治疗性应用抗抑郁剂有利于脑卒中失语患者的神经功能康复。

[Objectives] To test whether early antidepressive treatment with fluoxetine has any beneficial influence on the rehabilitation of stroke patients with aphasia.[Methods] A study involved 82 consecutive patients admitted to hospital for an acute stroke.The patients received treatment with or without fluoxetine（20 mg/d）.Before and at the end of the observation period,we assessed activities of daily living,degree of neurological deficit by MESSS and ADL for the subjects. [Results] In the 4 th week of the treatment,12 th week of the treatment and in the 12 th week of follow-up,the scores of MESSS for the treatment groups were 14.6,10.2,and 8.9 separately,comparing to the scores of control group（17.8,14.6,13.8）.The scores of ADL were 34.4,27.6 and 28.8 separately,comparing to the scores of control group（41.4,34.6,35.5） There were significant difference between the treatment and control groups（P0.01）.[Conclusion] Prophylactic antidepressive treatment with fluoxetine can improve the neurological function of post-stroke patients with aphasia.