E-cadherin-catenins粘附复合体与卵巢癌侵袭、转移和预后之间关系的研究进展

Research progress of the relationship between E-cadherin-catenins adhesion complex and the invasion,metastasis,and prognosis of ovarian cancer

卵巢癌是具有高度转移性的疾病而且是妇科恶性肿瘤的主要致死原因,对此病还没有很好的临床预测指标。E-cadherin-catenins粘附复合体在维持组织结构上起着重要作用,其异常表达与癌转移密切相关。本文对E-cadherin-catenins复合体在卵巢癌侵袭、转移及预后中所起的作用进行了综述。E-cadherin表达缺失或降低与卵巢癌组织分化低,侵袭、转移潜能强及预后差相关。

Ovarian cancer is a highly metastatic disease and the leading cause of death from gynecologic malignancy.There are no good clinical predictors of this disease.E-cadherin-catenins adhesion complex plays an important role in maintaining tissue architecture.The abnormal expression of this complex is associated with tumor metastasis.This review highlights recent progress in the effect of E-cadherin catenins complex on the invasion,metastasis,and prognosis of ovarian cancer.Loss or reduction of E-cadherin expression is related with poor histological differentiation,strong invasive and metastatic potential,and poor prognosis in ovarian cancer.